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2019

  Li S, Song Y, Quach C, Guo H, Jang GB, Maazi H, Zhao S, Sands NA, Liu Q, In GK, Peng D, Yuan W, Machida K, Yu M, Akbari O, Hagiya A, Yang Y, Punj V, Tang L, Liang C. (2019) . Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance.Nature Communications. doi: 10.1038/s41467-019-09634-8.


Li S, Jang GB, Quach C, Liang C. (2019). Darkening with UVRAG. Autophagy. doi: 10.1080/15548627.2018.1522911. Epub 2018 Sep 22.

2018

  

Yang Y, Jang GB, Yang X, Wang Q, He S, Li S, Quach C, Zhao S, Li F, Yuan Z, Lee HR, Zhong H, Liang C. (2018). Central role of autophagic UVRAG in melanogenesis and the suntan response.

PNAS doi: 10.1073/pnas.1803303115. 


Liang Q, Wei D, Chung B, Brulois KF, Guo C, Dong S, Gao SJ, Feng P, Liang C, Jung JU. (2018) Novel Role of vBcl2 in the Virion Assembly of Kaposi's Sarcoma-Associated Herpesvirus.

J Virology  doi: 10.1128/JVI.00914-17. Print 2018 Feb 15.

2017

Sparrer KMJ, Gableske S, Zurenski MA, Parker ZM, Full F, Baumgart GJ, Kato J, Pacheco-Rodriguez G, Liang C, Pornillos O, Moss J, Vaughan M, Gack MU. (2017). TRIM23 mediates virus-induced autophagy via activation of TBK1.Nature Microbiology. doi: 10.1038/s41564-017-0017-2. 


Guo J, Jayaprakash P, Dan J, Wise P, Jang GB, Liang C, Chen M, Woodley DT, Fabbri M, Li W.

(2017) PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion.Molecular Cell Biology doi: 10.1128/MCB.00171-17. 


Cheng J, Liao Y, Xiao L, Wu R, Zhao S, Chen H, Hou B, Zhang X, Liang C, Xu Y, Yuan Z. (2017) Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia.Cell Death Differentiation. doi: 10.1038/cdd.2016.121. 

2016

Yang Y, Quach C, Liang C. (2016) Autophagy modulator plays a part in UV protection.

Autophagy. doi: 10.1080/15548627.2016.1196319. 


Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O'Connell D, Zhang T, Pirooz SD, Jeon YH, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C. (2016). Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase.

Molecular Cell doi: 10.1016/j.molcel.2016.04.014.


O'Connell D, Liang C. (2016). Autophagy interaction with herpes simplex virus type-1 infection.Autophagy. doi: 10.1080/15548627.2016.1139262. 


Chimge NO, Little GH, Baniwal SK, Adisetiyo H, Xie Y, Zhang T, O'Laughlin A, Liu ZY, Ulrich P, Martin A, Mhawech-Fauceglia P, Ellis MJ, Tripathy D, Groshen S, Liang C, Li Z, Schones DE, Frenkel B. (2016). RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer.Nature Communication. doi: 10.1038/ncomms10751.


Kliionsky DJ… Liang, C…. (and 218 authors). Guidelines for the use and interpretation of assays for monitoring autophagy (3rdedition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. No abstract available. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]

2015

Yang Y, Liang C. (2015). MicroRNAs: an emerging player in autophagy.ScienceOpen Research 

doi: 10.14293/S2199-1006.1.SOR-LIFE.A181CU.v1. 


He S, Liang C. (2015) Frameshift mutation of UVRAG: Switching a tumor suppressor to an oncogene in colorectal cancer.Autophagy. doi: 10.1080/15548627.2015.1086523. 


He S, Zhao Z, Yang Y, O'Connell D, Zhang X, Oh S, Ma B, Lee JH, Zhang T, Varghese B, Yip J, Dolatshahi Pirooz S, Li M, Zhang Y, Li GM, Ellen Martin S, Machida K, Liang C. (2015). Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers.Nat Communication. doi: 10.1038/ncomms8839.


Minassian A, Zhang J, He S, Zhao J, Zandi E, Saito T, Liang C, Feng P. (2015). An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction.PLoS Pathology. doi: 10.1371/journal.ppat.1005060. 


He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung JU, Zhang X, Feng P. (2015). Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production.Molecular Cell. doi: 10.1016/j.molcel.2015.01.036. Epub 2015 Mar 5.


Liang Q, Chang B, Lee P, Brulois KF, Ge J, Shi M, Rodgers MA, Feng P, Oh BH, Liang C, Jung JU. (2015). Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication.J Virol. (10):5308-17. doi: 10.1128/JVI.00102-15. Epub 2015 Mar 4.


Liang C, Oh BH, Jung JU. (2015). Novel functions of viral anti-apoptotic factors.

Nat Rev Microbiol. 2015 Jan;13(1):7-12. doi: 10.1038/nrmicro3369. Epub 2014 Nov 3. Review.

2014

Pirooz S, He S, O'Connell D, Khalilzadeh P, Yang Y, Liang C. (2014). 

Viruses customize autophagy protein for efficient viral entry.Autophagy. 2014 Jul;10(7):1355-6. doi: 10.4161/auto.29075. Epub 2014 May 15.


Pirooz SD, He S, Zhang T, Zhang X, Zhao Z, Oh S, O'Connell D, Khalilzadeh P, Amini-Bavil-Olyaee S, Farzan M, Liang C. (2014). UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2716-21. doi: 10.1073/pnas.1320629111. Epub 2014 Feb 3.


Coleman CB, McGraw JE, Feldman ER, Roth AN, Keyes LR, Grau KR, Cochran SL, Waldschmidt TJ, Liang C, Forrest JC, Tibbetts SA. (2014). A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo.

PLoS Pathog. 2014 Feb 6;10(2):e1003916. doi: 10.1371/journal.ppat.1003916. eCollection 2014 Feb.


He S, O'Connell D, Zhang X, Yang Y, Liang C. (2014). The intersection of Golgi-ER retrograde and autophagic trafficking.Autophagy. 2014 Jan;10(1):180-1. doi: 10.4161/auto.26917. Epub 2013 Nov 15.

2013

He S, Ni D, Ma B, Lee JH, Zhang T, Ghozalli I, Pirooz SD, Zhao Z, Bharatham N, Li B, Oh S, Lee WH, Takahashi Y, Wang HG, Minassian A, Feng P, Deretic V, Pepperkok R, Tagaya M, Yoon HS, Liang C. (2013). PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.

Nat Cell Biol. 2013 Oct;15(10):1206-1219. doi: 10.1038/ncb2848. Epub 2013 Sep 22.


Trisciuoglio D, De Luca T, Desideri M, Passeri D, Gabellini C, Scarpino S, Liang C, Orlandi A, Del Bufalo D. (2013). Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth.Neoplasia. 2013 Mar;15(3):315-27.

2012

Klionsky DJ, et al. (2012). Guidelines for the use and interpretation of assays for monitoring autophagy.Autophagy. 2012 Apr;8(4):445-544.


Zhao Z, Ni D, Ghozalli I, Pirooz SD, Ma B, Liang C. (2012) UVRAG: at the crossroad of autophagy and genomic stability.Autophagy. 2012 Sep;8(9):1392-3. doi: 10.4161/auto.21035. Epub 2012 Aug 13.


Kim HJ, Zhong Q, Sheng ZH, Yoshimori T, Liang C, Jung JU. (2012). Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking.J Cell Sci. 2012 Oct 15;125(Pt 20):4740-50. doi: 10.1242/jcs.100339. Epub 2012 Jul 13.


Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C. (2012). A dual role for UVRAG in maintaining chromosomal stability independent of autophagy.Dev Cell. 2012 May 15;22(5):1001-16. doi: 10.1016/j.devcel.2011.12.027. Epub 2012 Apr 26.


Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU. (2012). Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation.Cell Host Microbe. 2012 Mar 15;11(3):264-76. doi: 10.1016/j.chom.2012.01.018.


Liang C. (2012). Viral FLIPping autophagy for longevity.Cell Host Microbe. 2012 Feb 16;11(2):101-3. doi: 10.1016/j.chom.2012.01.012.

2011

Pirooz SD, Lee JH, Zhao Z, Ni D, Oh S, Liang C. (2011). Measurement of γHV68 infection in mice.J Vis Exp. 2011 Nov 22;(57). pii: 3472. doi: 10.3791/3472.


Lee G, Liang C, Park G, Jang C, Jung JU, Chung J. (2011). UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila.Dev Biol. 2011 Aug 15;356(2):588-97. doi: 10.1016/j.ydbio.2011.06.024. Epub 2011 Jun 25.


Oh S, Pirooz SD, Ni D, Zhao Z, Liang C. (2011). Anti-autophagic Bcl-2: Not just an innocent bystander.Autophagy. 2011 Feb;7(2):231-2. Epub 2011 Feb 1.


Ku B, Liang C, Jung JU, Oh BH. (2011). Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX.Cell Res. 2011 Apr;21(4):627-41. doi: 10.1038/cr.2010.149. Epub 2010 Nov 9.


Liang, C. (2011). Herpesviral interaction with autophagy. Journal of Bacteriology and Virology  41(4):1-11


Oh S, Xiaofei E, Ni D, Pirooz SD, Lee JY, Lee D, Zhao Z, Lee S, Lee H, Ku B, Kowalik T, Martin SE, Oh BH, Jung JU, Liang C. (2011). Downregulation of autophagy by Bcl2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis. Cell death and differentiation vol. 18,3 (2011): 452-64. doi:10.1038/cdd.2010.116

2010

Liang C, Jung JU. (2010). Autophagy genes as tumor suppressors.Curr Opin Cell Biol. 2010 Apr;22(2):226-33. doi: 10.1016/j.ceb.2009.11.003. Epub 2009 Nov 28. Review.


Oh S, E X, Hwang S, Liang C. (2010). Autophagy evasion in herpesviral latency.

Autophagy. 2010 Jan;6(1):151-2. Epub 2010 Jan 4. Review.


Liang C. (2010). Negative regulation of autophagy.Cell Death Differ. 2010 Dec;17(12):1807-15. doi: 10.1038/cdd.2010.115. Epub 2010 Sep 24. Review.

2009

Xu TX, Sotnikova TD, Liang C, Zhang J, Jung JU, Spealman RD, Gainetdinov RR, Yao WD.

J Neurosci. (2009) Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate.Nov 11;29(45):14086-99. doi: 10.1523/JNEUROSCI.0974-09.2009.


Lee JS, Li Q, Lee JY, Lee SH, Jeong JH, Lee HR, Chang H, Zhou FC, Gao SJ, Liang C, Jung JU. (2009). FLIP-mediated autophagy regulation in cell death control.Nat Cell Biol. 2009 Nov;11(11):1355-62. doi: 10.1038/ncb1980. Epub 2009 Oct 18.


E X, Hwang S, Oh S, Lee JS, Jeong JH, Gwack Y, Kowalik TF, Sun R, Jung JU, Liang C. (2009). Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68.PLoS Pathog. 2009 Oct;5(10):e1000609. doi: 10.1371/journal.ppat.1000609. Epub 2009 Oct 9.


Lee HR, Kim MH, Lee JS, Liang C, Jung JU. (2009). Viral interferon regulatory factors.

J Interferon Cytokine Res. 2009 Sep;29(9):621-7. doi: 10.1089/jir.2009.0067. Review.

2008 & EARLIER

Gack MU, Kirchhofer A, Shin YC, Inn KS, Liang C, Cui S, Myong S, Ha T, Hopfner KP, Jung JU. (2008). Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16743-8. doi: 10.1073/pnas.0804947105. Epub 2008 Oct 23.


Liang C, Lee JS, Jung JU. (2008).  

Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.

Semin Cancer Biol. 2008 Dec;18(6):423-36. doi: 10.1016/j.semcancer.2008.09.003. Epub 2008 Oct 2. Review.


Sir D, Liang C, Chen WL, Jung JU, Ou JH. (2008) Perturbation of autophagic pathway by hepatitis C virus.Autophagy. 2008 Aug;4(6):830-1. Epub 2008 Jul 8.


Liang C, Sir D, Lee S, Ou JH, Jung JU. (2008) Beyond autophagy: the role of UVRAG in membrane trafficking.Autophagy. 2008 Aug;4(6):817-20. Epub 2008 Jun 25.


Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, Jung JU. (2008). Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.Nat Cell Biol. 2008 Jul;10(7):776-87. doi: 10.1038/ncb1740. Epub 2008 Jun 15.


Ku B, Woo JS, Liang C, Lee KH, Jung JU, Oh BH. (2008). An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins.Autophagy. 2008 May;4(4):519-20. Epub 2008 Mar 6.


Ku B, Woo JS, Liang C, Lee KH, Hong HS, E X, Kim KS, Jung JU, Oh BH. (2008). Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68.PLoS Pathog. 2008 Feb 8;4(2):e25. doi: 10.1371/journal.ppat.0040025.


Liang C, E X, Jung JU. (2008). Downregulation of autophagy by herpesvirus Bcl-2 homologs.

Autophagy. 2008 Apr;4(3):268-72. Epub 2007 Oct 29. Review.


Feng P, Liang C, Shin YC, Xiaofei E, Zhang W, Gravel R, Wu TT, Sun R, Usherwood E, Jung JU. (2007). PLoS Pathog. 2007 Dec;3(12):e174.


Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, Liang C, Jung JU, Cheng JQ, Mulé JJ, Pledger WJ, Wang HG. (2007). Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis.Nat Cell Biol. 2007 Oct;9(10):1142-51. Epub 2007 Sep 23.


Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, Jung JU. (2007). TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.Nature. 2007 Apr 19;446(7138):916-920.


Liang C, Feng P, Ku B, Oh BH, Jung JU. (2007). UVRAG: a new player in autophagy and tumor cell growth.Autophagy. 2007 Jan-Feb;3(1):69-71. Epub 2007 Jan 27. Review.


Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU. (2006).  Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.Nat Cell Biol. 2006 Jul;8(7):688-99. Epub 2006 Jun 25.


Liang C, Rieder E, Hahm B, Jang SK, Paul A, Wimmer E. (2005). Replication of a novel subgenomic HCV genotype 1a replicon expressing a puromycin resistance gene in Huh-7 cells.

Virology. 2005 Mar 1;333(1):41-53.